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The overproduction of tyrosinase contributes to hyperpigmentation one of the biggest skin concerns that people with more melanated skin often have (though hyperpigmentation can affect skin tones across the spectrum)

EMBO Mol Med 2020;12:e11217

Published in 1955, in his paper Jerne envisaged 'The role of the antigen is neither that of a template nor that of an enzyme modifier

These oxidized fatty acids are also called oxylipins, and can be produced by vertebrates, fungi, or plants 58

Nat Rev Microbiol 2021;19:14154 2

Identifying these differences through advanced molecular and imaging techniques could help tailor ferroptosis-targeted interventions to specific subphenotypes, optimizing therapeutic efficacy