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When these adaptive mechanisms are overwhelmed by a chronic excess in nutrient supply, the chronic flux of FFAs promotes a state of lipotoxicity across different tissues (11)

Cell Struct Funct 28(5):419429

Disruption of the gut microbial communities in Crohns patients has been previously reported, however, these disruptions may either exacerbate disease pathologies or be a consequence of the chronic gut inflammation arising from genetic abnormalities that result in dysfunctional immune signalling