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Savikin et al., 2013)

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doi: 10.1164/rccm.201208-1460OC 47 GranowitzEVClarkBDMancillaJDinarelloCA

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It is estimated that nearly 80% of disease-related proteins in the human proteome belong to this undruggable category, which highlights the urgent need for innovative strategies to overcome this bottleneck [4, 5]