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Safely removing senescent cells is one of three approaches scientists are looking at in this area, alongside preventing cell damage in the first place, and stimulating stem cells to improve tissue regeneration once the senescent cells are cleared out

CD patients have been found to have also alterations in adherence junction protein expression

Furthermore, as an immediate effect, the abdominal, thoracic, and cranial cavities interact with each other (Depauw et al., 2019), and increased intra-abdominal pressure causes an increase in intracranial pressure (Malbrain and Wilmer, 2007

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3

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doi:10.1074/jbc.M114.606186