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Statements Author contributions KQ: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review and editing

Mice were observed for 6 h after surgery, and were then transferred to an experimental animal center for standardized feeding

Effect of ginseng total saponins combined with Coptis berberine on plasma BNP and myocardial cell calcium concentration in chronic heart failure rats

Deficiency of vitamin B12 may cause tiredness, weakness, constipation, loss of appetite, weight loss and megaloblastic anemia (a condition when red blood cells become larger than normal)

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Also, similar to the observations in the case of mrpl24 morphants, we did not observe any impact on survival or a major locomotion deficit in the crispants (Supplementary Fig