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MiR-16 overexpression reduced cell proliferation in vitro and tumor growth in mice by targeting directly the IGF1R with subsequent inhibition of the Raf1- Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2)-ERK1/2 pathway (77)

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A common feature of both probiotics assayed is their ability to modify colonic microflora, which was altered as a consequence of the TNBS-induced inflammatory process (Peran et al