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Conversely, ER stress can inhibit ferroptosis through the PERK-ATF4 pathway and HSPA5 upregulation

After the basement membrane is destroyed by tumor cells, cancer - associated (myo -) fibroblast (CAF) abound in the tumor environment (187)

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Metabolomics analysis based on nuclear magnetic resonance (NMR) and mass spectrometry showed that silibinin restrains glucose metabolism to impede the biosynthetic requirements of breast cancer cells and increases levels of BCAAs isoleucine, leucine, and valine, thereby inducing apoptosis in breast cancer (MDA-MB-468, MDA-MB-231, and BT-549) and prostate cancer (PC-3) cells [960, 961]