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DPP-IV-resistant, long-acting oxyntomodulin derivatives

Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 4), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification

A murine study involving 250 mg/kg/daily AOD9604 and 1mg/kg/day HGH for 14 days reported that obese mice lost 28% and 40% of their body weight, respectively [21]

Sublingual and transdermal formulations have shown negligible absorption in bioavailability studies

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Patients should be counseled on symptoms of cholecystitis and cholelithiasis