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Future studies should consider incorporating complementary methods, such as p62/SQSTM1 or electron microscopy, to achieve a more accurate and comprehensive evaluation

564 Likewise, primary astrocytes prepared from ALS post-mortem samples induced necroptosis of neurones in co-culture, 565 and transplantation of diseased astrocytes into the spinal cord triggered motor deficits and promoted motor neurones degeneration

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Vitamin B12 (cobalamin) is an essential water-soluble vitamin that supports: Red blood cell production Nervous system health Energy metabolism DNA synthesis Many people, especially those with plant-based diets, digestive issues, or fatigue, are deficient in B12

Recently, we reported that glycine deficiency led to impairment in the glycine conjugation pathway and resulted in a significant decrease in the elimination of endogenous and exogenous metabolites in individuals with severe obesity 11