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Description

A methodology for performing global uncertainty and sensitivity analysis in systems biology

Previously, we showed that TG2 mediates crystallin, caspase 3, and collagen crosslinking in response to oxidative stress, hypoxic stress, and DNA damage, which leads to cataract formation, apoptotic resistance, and fibrotic development, respectively 4,5,6

2b, 2c), while 462 labeled metabolites and 1018 isotopologues, covering 36 metabolic pathways, were identified using the U- 13 C glutamine tracer (Fig