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Oxygen is capable of forming damaging molecules called free radicals. These free radicals can cause damage to healthy cells in our body, which may lead to aging, disease, and disorders

MSCs secrete numerous anti-inflammatory cytokines, including IL-13, neurotrophin 3, ciliary neurotrophic factor and IL-10, and growth factors that aid tissue repair (70)

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The Role of the Immune System in Response to Muscle Damage

For example, in Drosophila , the E3 ligase Cul3 promotes K48-linked ubiquitination of tim at the daynight transition, facilitating its degradation and phase progression (Szab et al., 2018)