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A doctor can watch for early signs of side effects, adjust the dosage if needed, and make sure the therapy is being used responsibly

Importantly, co-treatment with the iron chelator deferoxamine (DFO) partially counteracts these PA-induced alterations in protein expression (Figure 5A)

This allows companies to make vague claims about "repairing" skin without having to prove those claims in large-scale human clinical trials

Although the resulting proteins may lack certain domains, they can retain partial function and offer a therapeutic alternative when full gene replacement is impractical