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As per the mechanism by which cisplatin initializes apoptosis, the main cellular events include an increase in the expression of Bax, the depolarization of mitochondrial membrane, the release of mitochondrial cytochrome c, and the activation of caspase-3

Deubiquitinating enzymes identify and excise the ubiquitin chains attached to the substrate proteins

Patients should also be educated on the hepatotoxic potential of e-cigarettes

ROS produced by erythroid NADPH contributes to the exacerbation of erythroid dysfunction by exacerbating cell stiffness resulting in the increase of hemolysis [142]

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Drug repurposing Repurposing established metabolic drugs further supports this integrated strategy