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Psychoneuroendocrinology (2014) 46:1422

Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options

In 2001, the results of the Basel Thyroid Study conducted at the end of the 1990s were published, and this study revealed that tiredness and fatigue often remained in people with hypothyroidism, despite thyroid hormone therapy

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High endothelial venules as potential gateways for therapeutics

In addition, tumor-associated macrophages (TAMs) express folate receptor (FR), which mediates folate uptake, suggesting that folate conjugates of therapeutic agents are potential immunotherapeutic tools for targeting TAMs (70)