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It's about preserving injection site integrity across months of weekly administrations while supporting two complementary metabolic processes

doi:10.1016/0009-2797(91)90033-4.

Moreover, recent evidence points to another driver of the disease: vitamin D deficiency [113, 114]

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This includes the dynamic interplay between host immune responses and bacterial evasion, the genetic mutations that confer classical drug resistance, the epigenetic regulation in bacterial persistence and adaptive changes in bacterial cell wall architecture and core metabolism