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2c), most cells in GCGR-deficient mice were mTOR and p-STAT3-S727 positive and accompanied by elevated VGF levels and hypersecretion of glucagon (Fig

In order to exclude any virus-dependent effects, we further investigated the T cell-dependent (TD) response in Gclc fl/fl Mb1-Cre + mice using a stronger, T cell-driven model of cytopathic viral infection

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M1 macrophages depend on iron for producing ROS, which are crucial for their ability to kill pathogens and tumor cells