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Alkaloids, nitrogen-containing organic compounds with substantial biological activity 56 , have been the subject of extensive research that led to the discovery of numerous alkaloidal drugs since their approval by the US Food and Drug Administration, including the antimalarial agent quinine and the analgesic morphine

472 Elevated extracellular mtDNA in synovial fluid and plasma correlates with autoantibody presence and inflammation, while mtDNA mutations in synovial tissues are associated with increased TNF- and IFN signaling, establishing a self-reinforcing inflammatory cycle

Inhibition of liver cancer HepG2 cell proliferation by enzymatically prepared low-molecular citrus pectin

(2016) 137:184151.e2

Data acquisition, processing, and data visualization were performed using the Flex software suite (FlexControl 3.4, ftmsControl 2.0, FlexImaging 4.1 and DataAnalysis 4.2) from Bruker Daltonics

ACS Nano 14:664675