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Both studies underscore the importance of CC classification to clinical practice and its potential to guide treatment decisions effectively, particularly at the early stages of the syndrome (Wiegert et al., 2020

The BBB, which, like a semipermeable membrane, consists of endothelial cells (ECs), foot processes from astrocytes, and pericytes, separates the CNS from the peripheral immune system so that naive T cells cannot cross the BBB, but activated T cells can [21]

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