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While elevated MMA blood concentration is considered the specific indicator of deficiency (19), other clinical assays are often used as biomarkers of vitamin B 12 status sometimes in combination

In a series of animal models of arthritis (spontaneous arthritis in K/BxN mice, antigen-induced arthritis (AIA), and collagen-induced arthritis (CIA)) breach in intestinal permeability (leaky gut) has been identified using various functional assays [1,2,3]

Sadly, its increasingly clear to me that the NHS (UK) has failed me with the time it took to achieve deficiency diagnosis (2+ years) and then infrequently poor / even refusal of treatment for a further 2 years

Why Choose Our Vitamin B12 Injections

The patients who achieve the best outcomes treat the blend as one component of a comprehensive approach

But if the deficiency is caused by an irreversible inability to absorb the vitamin, a lifelong treatment with pharmacological doses of B12 is needed