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Although these values already indicate oxidative or reductive stress conditions, the normal physiological range will be much narrowed in between these values

Controlled environments reduce this risk

We further speculated that loss of the extracellular GSH pool in gsh2 mutants could change the external environment and consequently affect extracellular redox homeostasis

The plasma concentrationtime profiles showed a rapid one-peak course until T max , followed by a multiphasic decrease, which probably reflected a distribution and elimination phase

This conversion can be inhibited by targeting mitochondrial ROS with antioxidants or selenium, further highlighting the importance of ROS in fibroblast-to-myofibroblast conversion [81, 82]