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Circulating MOTS-c is detectable in humans and declines with age, but no completed human trial of administered MOTS-c has read out

[PubMed: 11564680] 137

Enrolling 17,604 adults aged 45 or older with established cardiovascular disease and a BMI of 27 or higher (without diabetes), SELECT showed that semaglutide 2.4 mg reduced the composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke by 20% over a mean follow-up of nearly 40 months

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Complications As most cases of vitamin B12 deficiency or folate deficiency can be easily and effectively treated, complications are rare

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