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Recent estimates indicate that by 2050, the number of Americans with diabetes will have more than doubled, potentially affecting up to 33% of the adult population [3]

The overall physiological adaptation resulting from redox signaling cascades depends on the rate of accumulation of these reactive species, and the steady-state levels of enzymatic and non-enzymatic antioxidants [4], as well as the basal oxidation state of proteins with thiol-based redox switches [7-9]

doi: 10.1016/j.lanmic.2025.101073 2 El-MoamlyAAEl-SweifyMA

It is critical to recall that all of this data comes from preclinical models (rodent, porcine, in vitro) and limited case studies

Additionally, the study only used a tiny sample size, underscoring the requirement for additional study

Visible-light optical coherence tomography fibergraphy of the tree shrew retinal ganglion cell axon bundles