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In thyroid cancer, the synergistic interaction between the ERK and PI3K/Akt pathways leads to the epigenetic silencing of genes like PTEN, promoting tumor cell survival and invasion (Gmez Sez, 2011[41]

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10.1016/j.jep.2020.113552 89 WeiM.-p.YuH.GuoY.-h.ChengY.-l.XieY.-f.YaoW.-r

RSL3 subdued DNA damage repair response by suppressing phosphorylation of nucleophosmin 1 (NPM1)

This dual pro-inflammatory and pro-survival action provided a novel mechanistic explanation for the persistent inflammation observed in vitiligo lesions