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Description

During brain ischemia, the initiation of L-glu- (or L-asp-) mediated excitotoxicity occurs within minutes due to the rapid increase in extracellular cerebral L-glu (and L-asp

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doi: 10.2147/dmso.s322296 27

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By upregulating and activating SIRT1, which subsequently deacetylates and functionally inhibits STAT3, GHK-Cu entirely short-circuits the inflammatory cascade, promotes profound mucosal healing, and restores the integrity of tight junction proteins (such as ZO-1 and Occludin) within the cellular barrier

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