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They promote the expression of catabolic enzymes (e.g., MMP-1, -2, -3, -13, and ADAMTS-4/5) and inhibit anabolic proteins like aggrecan and collagen II by activating signaling pathways such as NF-B, MAPK, and Toll-like receptors (TLR), ultimately leading to ECM degradation and tissue destruction (Yang et al., 2025

Hsp70 chaperones: cellular functions and molecular mechanism

Monoiodotyrosine (MIT) and diiodotyrosine (DIT) are generated, where MIT and DIT Have a tyrosine residue with iodine and 2 molecules of iodine, respectively

4c), an observation that is in agreement with our biochemical analyses (Table 1)

A strong chin does something quietly powerful to a face

These are the most difficult scars to treat because they can extend far under the surface of the skin