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CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice

Hydroxyl radical (.OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells

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Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed

At the same time, TCM has long-term experience in human use, has better clinical safety, lower toxicity and side effects, and is often used in combination with chemical medicine to achieve synergistic effect

In agreement with a role of HMOX1 as a driver of immunosuppression, myeloid-specific HMOX1 deletion restored CD8 + T cell function and enhanced the therapeutic efficacy of antitumor vaccines [80]