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Pourmasumi et al., 2023)

308 Experimentally-induced depletion or attenuation of reactive astroglia markedly exacerbates the clinical progression, spread of inflammation and tissue loss in EAE during the induction phases of the disorder, 81,309,310 whereas similarly induced depletion of proliferating reactive astrocytes at later times during the progressive phase ameliorates disease, and this amelioration is at least in part due to removal of astrocyte Ccl2 production

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While the back pain usually starts to ease up in six to eight weeks, how manageable that is for the patient depends on the specifics of the case and the patient himself