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When administered orally, up to 23% of individuals experience gastrointestinal problems such as nausea and vomiting, which are the most frequent side effects

This suggests that when aiming to enhance ATP production by increasing TCA cycle flux, it is essential to consider the interplay between glycolysis and the TCA cycle, as excessive TCA cycle activity may suppress glycolysis

Male rats with PTSD-like behaviors showed elevated p -cresol (a neurotoxic metabolite linked to overgrowth of Ruminococcaceae and Lachnospiraceae ) in prefrontal cortex, leading to dopaminergic dysfunction with increased DA, increased dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and significantly elevated DA D3 receptor expression compared to controls (Laudani et al., 2023)

doi: 10.1038/s41538-024-00348-w 188

NCOA4: More than a receptor for ferritinophagy

Antipsychotic efficacy of evenamide (NW-3509) is due to modulation of glutamatergic dysregulation