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The most investigated mechanisms with known clinical significance are: a) activation of transmembrane proteins effluxing different chemical substances from the cells (P-glycoprotein is the most known efflux pump)

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That distinction can matter when reading literature or analytical records

However, the intranasal route of drug delivery still has some unresolved issues, such as the need to overcome cilia and mucosal clearance in the vestibular region, as well as enzymatic degradation after the introduction of nanotherapeutic formulations into the nasal cavity[166]

Metabolic trade-offs in yeast are caused by F1F0-ATP synthase

This approach has been previously used to evaluate the efficacy of anti-EBV mAbs and vaccine-elicited antibodies 24,26,27,34,35