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However, they often show direct RS scavenging or other biological activity (e.g., inhibition of topoisomerase II)

Key Clinical Distinction Vitamin B12 treats a specific deficiency with defined risks if left untreated

Supplemental Benefits

When the drug cannot reach sufficient intracellular concentrations, the cells may survive through intrinsic drug resistance mechanisms and gradually evolve into drug-resistant tumors

BRs have been shown to be effective even in micromolar concentrations

Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)