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Pigmentation & Skin-Integrity Research Research involving Glutathione commonly investigates its interaction with: Tyrosinase-related mechanisms Melanin-related signaling pathways Oxidative-stress regulation within melanocyte research models Skin-integrity and dermal-maintenance pathways These pathways have contributed to broader research interest in Glutathione within pigmentation-related, dermatological, cosmetic, and skin-quality investigations

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We observed an upregulation in the mRNA expression levels of Nrf-2 and HMOX-1 in both HEK293T and HK-2 cells exposed to iron (Figures 4EH), indicating the activation of antioxidant response pathways in response to increased oxidative stress

Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants

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