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Finally, this review summarized the potential mechanisms of resistance to anti-angiogenic therapy in reversing drug resistance in breast cancer immunotherapy

In humans, CYP3A is readily induced by xenobiotics, is activated by CYP3A inducers, and leads to activation of PXR (Kliewer 2003

Paradoxically, preservation of OXPHOS under these conditions exacerbates ROS production and lipid peroxidation, ultimately promoting ferroptosis in cancer cells 210,211

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