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However, it is worth considering that caspase-3 may be involved in non-apoptotic processes, particularly in neuronal cells, where it supports mechanisms of synaptic plasticity and neural regeneration, as well as contributes to the removal of damaged cellular components without inducing cell death [65]

Some studies demonstrated that GST gene polymorphism carries have a positive correlation with brain cancer, Alzheimers disease, and Parkinsons disease development risk [54]

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The human gamma-glutamylcysteine synthetase enzyme is a dimer consisting of a heavy (catalytic) and a light (regulatory) subunit

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However, this pathway acts on the "upstream" of ferroptosis, so it cannot prevent ferroptosis induced by the GPX4 inhibitor RLS3