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PMID: 33119202

261 Pyruvate kinase M2 (PKM2), another key glycolytic enzyme, is stabilized by the deubiquitinase USP20, making USP20 a potential therapeutic target

Common inhibitors currently include oroxylin A [52] and oxythiamine (OT) [53]

If successful across all indications, retatrutide could receive approval for weight management , type 2 diabetes, cardiovascular risk reduction, knee osteoarthritis, and liver disease

For a closer look at how this antioxidant works in the body, you may also like our guide on Understanding How Glutathione Works in Our Body

Although most frequently diagnosed in Japan, there have been cases diagnosed worldwide in patients of other ethnicities, including some predisposed individuals identified in Turkish and Sicilian populations (49)