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"In concrete terms, we advise these patients to guard their physical limits and not to exceed them," said Brent Appelman, a researcher at Amsterdam UMC

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

Blood Cancer 57 , 549553 (2011)

The affected side of the face becomes droopy and prevents normal smiling or eye closure

doi: 10.1038/s42003-021-01741-x 74 MaierISchiestlRH

site-rotate across abdomen, thighs and upper arms