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Subsequent interest in AOD-9604 has been limited to niche research areas, particularly osteoarthritis, where intra-articular injection might bypass systemic bioavailability limitations

With these values, the LDL cholesterol (LDL-C) concentration can be estimated

In the mouse heart, USP1 expression is markedly higher than the other BMAL1 deubiquitinases, USP2 and USP9X , while in the hypothalamus USP9X was much higher than the others ( USP1 playing a dominant role in cardiac circadian regulation

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