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32 The positive association between frequency of MTHFR -C677T and MTHFR -A1298C polymorphisms and latitude documented in the current study suggests that in areas closer to the equator, which are increasingly exposed to UVR, activity of the MTHFR enzyme reflects greater functional competency because of the absence of the MTHFR polymorphisms

TNF measurement was also used with Meso Scale Discovery human cytokines (MSD, Rockville, MD)

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Activation of Microglia and Astrocytes : These cells can adopt phenotypes with distinct functions