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Toxicological studies have shown that PSO can lead to multisystem damage, including to the reproductive, immune, and nervous systems, as well as to substantial organs such as the liver and kidneys, with the liver being particularly severely affected (Wang X

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has revealed its antiremodeling effects by lowering the heart weight index and hormone levels in thyroxine- or aortic ligation-induced models (94)

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A oligomers are well-recognized cytotoxic species capable of triggering neurodegeneration

So the over the counter stuff, I do believe that federal law speaks to that and I think that it's probably enforced by the FDA