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Recent research determined that aryl hydrocarbon receptor (AhR) activation after alcohol intake in the liver, which is mediated by Protein Phosphatase 2 Regulatory Subunit-Bdelta (Ppp2r2d) to promote AMPK dephosphorylation, leading to autophagy inhibition and mitochondrial dysfunction (Kim et al., 2022)

In fact the ELF concentration of GSH is 140 times that of blood serum concentrations with a redox ratio of greater than 9:1

(2002) Oxidative stress in Portuguese children with Down syndrome

Epigenetics 8, 43

Direct application of ROS over a relevant time course to tissues at concentrations found in vivo should reproduce damage similar to that observed in the diseased tissue

A., Kanaki, T., Slominski, A