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All steps search, selection, appraisal, and synthesis were prespecified in a protocol stored in an internal repository and are reported here in plain narrative form

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They regulate key biological processes such as inflammation, cellular migration, proliferation, and angiogenesis [19, 20]

In particular, carrier family 38 member 1 (SLC38A1)- and SLC1A5-mediated l-glutamine (but not d-glutamine) uptake and subsequent glutaminase 2 (GLS2, but not GLS1)-mediated glutamate production is required for cystine deprivation- or erastin-induced ferroptosis 40 (Fig