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In addition, GABARs, to which GABA, an inhibitory neurotransmitter, binds, are the most important target to control seizures and treat epilepsy

Notably, rs6742078 is an SNP in the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene ( 2 of rs6742078 was 23.93% in our study, which indicated that it was a strong IV for plasma bilirubin, we included this SNP although it was filtered out of the SNP pool during the clumping process

Oxidative stress causes cellular damage and accelerates neuro-degeneration by inducing the reactive oxygen species (ROS) that oxidize vital cellular components such as lipids, proteins and DNA [41, 42]

doi: 10.1016/j.biopha.2019.108612

doi: 10.1007/s00018-002-8520-9 49 BabiorBLambethJNauseefW

Impairment of SELENOS is directly associated with increased cellular cytokine production and release (Reference Curran, Jowett and Elliott65)