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An overview of the pathway of melanin synthesis and the site of action of the most commonly used systemic skin whitening agent (glutathione [GSH]) is depicted in [Figure - 1]

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Disclosure of interest: RJvO and WHvZ report financial support for the current manuscript from the Collaboration for New Treatments of Acute Stroke (CONTRAST) consortium (which was financed for the current study by the Netherlands Cardiovascular Research Initiative, an initiative of the Dutch Heart Foundation, the Netherlands Brain Foundation, Stryker, Medtronic, and Cerenovus), all paid to their institution

Ideally, begin your preparation phase two to four weeks before your first AOD-9604 dose