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of this final rule with comment period, we once again proposed, with modifications (as discussed in section XX.C.2

Figure 2 2.1.3 Iron metabolism and ferroptosis Iron is an essential trace element in the human body, playing multiple important biological roles, including inducing ATP production, participating in DNA and hemoglobin synthesis, and many other physiological activities ( Fe 3+ ions are reduced to Fe 2+ ions and then transported and stored in the cellular iron pool, while excess Fe 2+ ions are stored in ferritin ( 2+ ions, inducing the production and accumulation of large amounts of ROS through the Fenton reaction, ultimately promoting cell ferroptosis ( TFRC is the gene encoding the transferrin receptor

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Additional contributors include excess body weight, smoking, sedentary behavior poor postural control, psychological factors such as depression, anxiety, catastrophizing, job dissatisfaction, and low socioeconomic status [24,28,29,30,31,32,33,34]

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