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Description

To determine the underlying mechanism of mitoxyperiosis, Wang and colleagues screened a library of 2050 small molecules, targeting ~1000 cellular pathways

doi:10.1073/pnas.84.8.2377

10.1093/cvr/cvp177 Cardiovasc

Only when BPC 157 was cumulatively added up to 10 or 100 g/ml, the increase of vasorelaxation became prominent

Although initially suggested to act via recruiting HDAC3, Xist-mediated silencing is abolished by SHARP deletion, but only attenuated upon HDAC3 deletion 48,49 , suggesting that additional mechanisms are involved in SHARP-dependent repression of the X-chromosome