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Int J Mol Sci 17(11):1810 Zuo K, Tang K, Liang Y, Xu Y, Sheng K, Kong X, Wang J, Zhu F, Zha X, Wang Y (2021) Purification and antioxidant and anti-Inflammatory activity of extracellular polysaccharopeptide from Sanghuang mushroom, Sanghuangporus lonicericola

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ABCA1 adenosine triphosphate-binding cassette transporter A1 AMD age-related macular degeneration ATP adenosine triphosphate COX cyclooxygenase COX-2 cyclooxygenase-2 CRP C-reactive protein DDR DNA damage response ERK extracellular signal-regulated kinase GLUT1 glucose transporter type 1 GSNO S-nitroglutathione GST -glutathione S-transferase HDL high-density lipoprotein HGPS Hutchinson-Gilford progeria syndrome HO-1 heme oxygenase-1 H2O2 hydrogen peroxide ICAM-1 intercellular adhesion molecule 1 IKK IB kinase IL-1 interleukin-1beta iNOS inducible nitric oxide synthase IL-6 interleukin-6 JNKs c-Jun N-terminal kinases LPS lipopolysaccharide MAPKs mitogen-activated protein kinases MHC major histocompatibility complex MMP-1 matrix metalloproteinase-1 NADH nicotinamide adenine dinucleotide NADPH nicotinamide adenine dinucleotide phosphate NADPH-oxidase nicotinamide adenine dinucleotide phosphate-oxidase NCDs non-communicable diseases NF-B nuclear factor-kappa B NO nitric oxide Nrf-2 nuclear factor E2-related factor 2 O2 oxygen O2 superoxide OH hydroxyl radical ONOO peroxynitrite oxLDL oxidized-low density lipoprotein PAI-1 plasminogen activator inhibitor-1 PGs prostaglandins PGG2 prostaglandin G2 PGH2 prostaglandin H2 PKC protein kinase C PPAR peroxisome proliferator-activated receptor gamma PP2A phosphoprotein phosphatase 2A PUFAs polyunsaturated fatty acids RANKL receptor activator of nuclear factor kappa B ligand RNS reactive nitrogen species ROS reactive oxygen species SAPS senescence-associated secretory phenotype TGF- transforming growth factor beta TNF- tumor necrosis factor- TPP triphenylphosphonium Trx thioredoxin UQ ubiquinone VCAM-1 vascular cell adhesion molecule 1 5-LOX 5-lipoxygenase

4.4 Transcriptomics and growth control transcription factors Transcriptomic analyses are actively exploring the role of growth-regulatory TFs in skin aging

A meta-analysis of the impact of ALA on weight and BMI demonstrated that the mean weight and BMI reductions observed in the ALA group were significantly greater than those observed in the placebo group [70]

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