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Macrophage foam cell formation and cholesterol dependent inflammatory receptor signaling can be reduced by the removal of cholesterol by atheroprotective HDL and apoA-I via a number of mechanisms including ABCA1, ABCG1, SR-BI, and aqueous diffusion (Figure 2) (61,66-68) (see details below)

As a result, investigations have shown that nanoprobiotics and nanoprebiotics are effective therapies for dysbiosis (129)

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The review highlights the necessity for further research into natural antioxidants to develop more effective treatment strategies for DN