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Structure of membrane-embedded region Anchored in the upper region of the lipid bilayer, two amphipathic helices form the MPR, which extends below DI before turning back towards the centre of the trimer where the connection to the transmembrane domain (TMD) is located (Figs

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It has been reported that glutamine and glutaminolysis are required for cysteine starvation and erastin-mediated ferroptosis [85, 86]

Choi YB, Lipton SA (2000)