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Chemical uncouplers such as dinitrophenol increase the number of fatty acids thatmust be oxidized perATPmade, and once were used as diet pills.Natural uncoupling proteins (UCPs) were later discovered and shown to be involved with regulation of energy balance and heat generation (including in some adults)

Prescription options can be invasive, expensive, or come with side effects

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Toporkova, Y.Y., Smirnova, E.O., Gorina, S.S

Mol Cell Proteomics 3 , 501509, doi: 10.1074/mcp.M300132-MCP200 (2004)

Whereas CD5 and IL-2 influence immune system functions and MMP2 is important in maintaining the extracellular matrix in skin, tendons and other connective tissue, and Tram1 increases protein production