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We approached the question of the potential relevance of NQO1 in superoxide scavenging in cells using an NQO1 transfected series of Chinese hamster ovary cells (Siegel et al., 2004)

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Additionally, ROS can also trigger other cell death events in lens epithelial cells, such as apoptosis characterized by upregulation of the pro-apoptotic Bcl-2-associated X protein ( BAX ) gene and downregulation of the anti-apoptotic B-cell lymphoma-2 ( BCL-2 ) gene [30] as well as pyroptosis mediated by ROS-induced activation of the NLRP3 inflammasome/caspase 1/gasdermin D pathway [31]

Svitkin YV, Cheng YM, Chakraborty T, Presnyak V, John M, Sonenberg N

thus, it changes the activity of enzymes ( Figure 2