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Thus, an overactive neuroinflammatory response of astrocytes and microglia can contribute to BD development by alterations in immune response that leads to an increase in not only BBB integrity but also in intestinal permeability [147]

Sources: PMID 18271889, 36986081, 38320260, 38365549, 39186190, 40005053 Saffron is having a moment its kind of amazing because its the most expensive spice in the world yet all of these benefits keep popping up around what it can do as a Supplement

10.1042/BSR20201807 71 GuoJ.XuB.HanQ.ZhouH.XiaY.GongC.et al (2018)

L, Z., Sang, L., Li, Z., and Min, H., Ecotoxicol

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